学术动态
当前位置:首页 >> 学术动态
2016-2017学年第一学期航空航天系第七期学术讲座
发表时间:2016-10-23 阅读次数:503次

题目:Organoids on chips fordrug testing applications
主讲:Hanry Yu Professor
主持:邓道盛研究员
时间:2016年10月25日(周二)上午10:00
地点:光华楼东主楼2601室


教授简介
Prof. Marie-Jean Thorav​ Dr. Hanry Yu is a professor ofPhysiology and Mechanobiology at the National University of Singapore; andgroup leader at the Institute ofBioengineering and Nanotechnology, A*STAR. He was trained in Cell Biology at Duke University and then EMBL, Germany.Dr. Yu ventured into Biomaterials, tissue engineering and lab on chip research in late 1990s focusing onenvironmental controls for micro-liver tissue constructs. He publishes extensively in these areasand in biomedical optics, computation and systems biology, and recently in mechanobiology. Dr. Yuchampioned 3 interdisciplinary PhD programs in Singapore; and advisesvarious government and industry entities.He filed over 40 patents and licensed 6 patents and spun off 3 spuncompanies and one listed as a public company.Since 2008, Dr. Yu has been visiting professor in MIT (USA) and recently Southern Medical University(China); and a handling editor of Biomaterials.


内容简介
Organoidshave become increasingly popular as disease or drug testing models as theyrecapitulate more in vivo structures and functions than theconventional 2D culture. The control of organoid size in extended culturepose much challenges. We have developeda range of micro-fabricated solutions to tackle these challenges and enable the intended drug testingapplications. Organoids can be pre-formed or concurrently formed in chips.Chemical inter-cellular dendrimer linkers,sugar-based substrates and compaction forces facilitated the rapid in chipformation of the organoids. Micro-porous ultrathin membranes can immobilise organoids to maintain optimal mass transfer and minimise shear stress thusstabilising organoid sizes within diffusion limits over extended culture.Balancing between perfusion anddiffusion enable the multi-organ mimicry chip to model physiology-basedpharmacokinetics properties. Eventually, anincubator on chip enables extended culture to be executed on chip with minimal movement and contamination.We are moving towards an era of personalised medicine where patient samples can be used in organoids on chipsfor tailoring patient specific therapy.

Copyright © 2013 复旦大学航空航天系   旧版入口

上海市邯郸路220号  电话:021-65642741 传真:021-65642742

技术支持:维程互联